Comparative Efficacy of Intravenous Ketamine and Antidepressant Augmentation

This study evaluates the efficacy of intravenous (IV) ketamine and antidepressant augmentation in patients with difficult-to-treat depression (DTD). Through a comparative analysis of symptom reduction and effect size, the study aims to determine the relative effectiveness of these treatment modalities. Results indicate that IV ketamine provides a more substantial reduction in depressive symptoms compared to antidepressant augmentation alone, with a larger effect size.